A fresh set of 20 random questions is generated every time you open this page and every time you refresh it.For each of the following multiple choice questions, choose the most appropriate answer :
1. The term necrobiosis implies :
A. Sudden necrosis
B. Necrosis followed by degeneration
C. Extensive necrosis
D. Necrosis preceded by degeneration
2. Regarding granulomatous inflammation, one of the following is INCORRECT.
A. central caseous necrosis is rare in all granulomatous diseases EXCEPT tuberculosis.
B. both Langerhan’s and foreign-body type giant cells may be seen in the granulomas of sarcoidosis.
C. acid fast bacilli are seen in leprosy and tuberculosis
D. fungal infections cannot result in granulomas
3. A synonym for amyloidosis is :
A. alpha-fibrillosis
B. beta-fibrillosis
C. gamma-fibrillosis
D. Cysteinosis
4. A 50-year old patient presents with weakness and bleeding episodes. His hemoglobin was 10.5 g/dL. His leukocyte count was 48*109 cells/L and platelet count was 50*109 cells/L. There was dysplasia of neutrophilia with a differential count showing 76% neutrophils, 8% blast cells, 12% myelocytes and metamyelocytes and 4% other cells. Bone marrow examination showed 14% blasts. Cytogenetics showed t(8,21). The most likely diagnosis is
A. Acute myeloid leukemia
B. Chronic myeloid leukemia
C. Chronic lymphoid leukemia
D. Myelodysplastic syndrome
5. A female presents with history of progressive breathlessness. Histology shows heterogenous patchy fibrosis with several fibroblastic foci. The most likely diagnosis is:
A. Cryptogenic organizing pneumonia
B. Non specific interstitial pneumonia
C. Usual interstitial pneumonia
D. Desquamative interstitial pneumonia
6. PNH is associated with deficiency of:
A. DAF (Decay accelerating factor)
B. MIRL (Membrane inhibitor of reactive lysis)
C. GPI Anchored Protein (Glycosyl phosphatidyl inosital anchored proteins)
D. LFA (Lymphocyte function associated antigen)
7. Which of the following have most friable vegetation?
A. Infective endocarditis
B. Libman Sack's endocarditis
C. Rheumatic heart disease
D. SLE
8. The macrophages involved in inflammation originate from :
A. Monocytes
B. Tissue cells
C. Giant cells
D. Lymphocytes
9. The first-born infant of an Rh-negative 26 year old woman, who had two previous second trimester abortions, has severe haemolysis and circulatory failure. This most likely could have been prevented by treating the mother with:
A. a combination of IgG and IgM anti-D antibodies.
B. anti-D IgG during the mother's most recent pregnancy.
C. anti-D IgG upon termination of each of the first two pregnancies.
D. anti-D IgM during the mother's most recent pregnancy
10. With regard to eicosanoids
A. main action of LTB4 is to increase permeability.
B. PGE2 causes intense vasoconstriction.
C. permeability increase caused by LTD4 restricted to venules.
D. LTC4, LTD4, LTE4, are important vasodilators
11. Polyarteritis nodosa is preceded by a history of :
A. Bee-sting
B. Drowning
C. Trauma
D. Bronchial asthma
12. A 50- year old male presents with large bowel type diarrhea and rectal bleeding. On sigmoidoscopy, a cauliflower like growth is seen in the rectum. Colectomy specimen on histopathology shows adenocarcinom. Which of the following prognostic investigations is not required?
A. Microsatellite instability
B. c-myc mutations
C. EGFR mutations
D. k-RAS mutations
13. The most convenient site for biopsy to confirm secondary amyloidosis is :
A. Kidney
B. Heart
C. Rectum
D. Pancreas
14. Autopsy finding of voluminous and emphysematous lungs filling the entire pleural cavities, indicates :
A. Bronchiectasis
B. Bronchial asthma
C. Dhatura poisoning
D. Congestive cardiac failure
15. Plasmacytoid lymphomas may be associated with:
A. IgG
B. IgM
C. IgA
D. IgE
16. PNH is associated with deficiency of:
A. DAF
B. MIRL
C. GPI Anchored protein
D. All of the above
17. A young female is most likely to develop :
A. Polyarteritis nodosa
B. Temporal arteritis
C. Aortic arch syndrome
D. Wegener's granulomatosis
18. The total leucocyte count in acute myeloblastic leukaemia is :
A. 5,000-10,000
B. 20,000-25,000
C. 40,000-50,000
D. 50,000-100,000
19. Most commonly, amyloidosis is secondary to :
A. Chronic suppuration
B. Acute inflammation
C. Cellular necrosis
D. Hyaline degeneration
20. Electron microscopy is diagnostic in:
A. Goodpasture's syndrome
B. Alport's syndrome
C. Wegener's syndrome
D. Chung strauss syndrome
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